Antimicrobial therapy for rheumatoid arthritis
Identifieur interne : 002B82 ( Main/Exploration ); précédent : 002B81; suivant : 002B83Antimicrobial therapy for rheumatoid arthritis
Auteurs : M. Kloppenburg ; B. A. C. Dijkmans ; F. C. BreedveldSource :
- Bailliere's Clinical Rheumatology [ 0950-3579 ] ; 1995.
English descriptors
- Teeft :
- Adverse effects, Antibiotic, Antimicrobial, Antimicrobial agents, Antimicrobial chemotherapy, Antimicrobial therapy, Arthritis, Beneficial effect, Bone resorption, British journal, Chemotherapy, Clinical parameters, Collagenase, Collagenase activity, Comparative study, Doxycycline, Experimental rheumatology, Forsgren, Golub, Human monocytes, Inhibitory effect, Kloppenburg, Laboratory parameters, Leukocyte, Lymphocyte, Minocycline, Mitochondrial protein synthesis, Neutrophil, Open studies, Open study, Periodontal research, Placebo, Protein synthesis, Ramamurthy, Reactive, Reactive arthritis, Rheumatic, Rheumatic diseases, Rheumatoid, Rheumatoid arthritis, Rheumatology, Scandinavian journal, Tetracycline, Therapeutic effect.
Abstract
Summary: New interest in the use of antibiotics in the treatment of arthritis was stimulated by two factors: (1) observations that, in some forms of chronic arthritis, microbial antigens persist in the synovial membrane, and (2) the increasing knowledge of the anti-inflammatory and immunosuppressive effects of antibiotics. Recently, several published controlled studies reported a beneficial effect of tetracyclines on RA and reactive arthritis. Whether the anti-arthritic activity of the tetracyclines investigated is mediated by the antimicrobial, anti-inflammatory or immunomodulatory properties remains to be determined. It may be concluded from these studies that tetracyclines have a beneficial effect on RA, especially when laboratory parameters are considered. The effect on the clinical parameters is not unequivocal. The adverse effects seem to be mild but the long-term efficacy and safety of tetracyclines as disease-modifying antirheumatic drugs remain to be demonstrated.
Url:
DOI: 10.1016/S0950-3579(05)80312-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000325
- to stream Istex, to step Curation: 000325
- to stream Istex, to step Checkpoint: 001973
- to stream Main, to step Merge: 002C40
- to stream Main, to step Curation: 002B82
Le document en format XML
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<term>Antimicrobial therapy</term>
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<term>Beneficial effect</term>
<term>Bone resorption</term>
<term>British journal</term>
<term>Chemotherapy</term>
<term>Clinical parameters</term>
<term>Collagenase</term>
<term>Collagenase activity</term>
<term>Comparative study</term>
<term>Doxycycline</term>
<term>Experimental rheumatology</term>
<term>Forsgren</term>
<term>Golub</term>
<term>Human monocytes</term>
<term>Inhibitory effect</term>
<term>Kloppenburg</term>
<term>Laboratory parameters</term>
<term>Leukocyte</term>
<term>Lymphocyte</term>
<term>Minocycline</term>
<term>Mitochondrial protein synthesis</term>
<term>Neutrophil</term>
<term>Open studies</term>
<term>Open study</term>
<term>Periodontal research</term>
<term>Placebo</term>
<term>Protein synthesis</term>
<term>Ramamurthy</term>
<term>Reactive</term>
<term>Reactive arthritis</term>
<term>Rheumatic</term>
<term>Rheumatic diseases</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Rheumatology</term>
<term>Scandinavian journal</term>
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<front><div type="abstract" xml:lang="en">Summary: New interest in the use of antibiotics in the treatment of arthritis was stimulated by two factors: (1) observations that, in some forms of chronic arthritis, microbial antigens persist in the synovial membrane, and (2) the increasing knowledge of the anti-inflammatory and immunosuppressive effects of antibiotics. Recently, several published controlled studies reported a beneficial effect of tetracyclines on RA and reactive arthritis. Whether the anti-arthritic activity of the tetracyclines investigated is mediated by the antimicrobial, anti-inflammatory or immunomodulatory properties remains to be determined. It may be concluded from these studies that tetracyclines have a beneficial effect on RA, especially when laboratory parameters are considered. The effect on the clinical parameters is not unequivocal. The adverse effects seem to be mild but the long-term efficacy and safety of tetracyclines as disease-modifying antirheumatic drugs remain to be demonstrated.</div>
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